Enalaprilat

ENALAPRILAT

Manufacturer: Dr. Reddys Laboratories Inc

Score: 147.0

Quick Summary

Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension when oral therapy is not practical. It works by inhibiting the conversion of angiotensin I to angiotensin II, leading to decreased vasopressor activity and aldosterone secretion. The usual dose is 1.25 mg every six hours administered intravenously over a five-minute period. Enalaprilat is generally well-tolerated, but it can cause hypotension, especially in patients with heart failure, hyponatremia, or those taking diuretics. It is contraindicated in patients with a history of angioedema related to ACE inhibitors and in those with hereditary or idiopathic angioedema. Special considerations are needed for use in pregnancy, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

Treatment of hypertension when oral therapy is not practical
Inhibition of angiotensin-converting enzyme (ACE)
Decreased vasopressor activity and aldosterone secretion

Important Safety Information

Warning

Enalaprilat can cause excessive hypotension, especially in patients with heart failure, hyponatremia, or those taking diuretics

Contraindications

History of angioedema related to ACE inhibitors
Hereditary or idiopathic angioedema

Adverse Reactions

Hypotension
Angioedema
Anaphylactoid reactions
Neutropenia/Agranulocytosis
Hepatic failure

Dosing Recommendations

General Guidance

Dose adjustments may be necessary in patients with renal impairment or those taking diuretics

Hypertension

Adult Dose

1.25 mg every six hours administered intravenously over a five-minute period

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Category C (first trimester) and D (second and third trimesters)
Can cause fetal and neonatal morbidity and mortality

Nursing Mothers

Enalapril and enalaprilat are detected in human breast milk
Decision should be made to discontinue nursing or the drug

Pediatric Use

Safety and effectiveness not established

Geriatric Use

Dose selection should be cautious, starting at the low end of the dosing range
Consideration of decreased hepatic, renal, or cardiac function