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FENTANYL TRANSDERMAL

FENTANYL TRANSDERMAL

Manufacturer: SpecGx LLC

Score: 144.0

Quick Summary

Fentanyl Transdermal is used for the management of severe and persistent pain in opioid-tolerant patients. It is a transdermal patch that releases fentanyl, an opioid agonist, over a 72-hour period. The patch is available in various strengths, and the dosage is individualized based on the patient's prior opioid usage and their response to the medication. Fentanyl Transdermal has several warnings and precautions, including the risk of addiction, abuse, and misuse, as well as the potential for respiratory depression, especially when used in combination with other CNS depressants. The medication is contraindicated in patients who are not opioid-tolerant, and it should be used with caution in patients with certain medical conditions, such as respiratory depression, bronchial asthma, and gastrointestinal obstruction.

Key Clinical Findings and Indications

  • Management of severe and persistent pain in opioid-tolerant patients
  • Transdermal patch that releases fentanyl over a 72-hour period
  • Available in various strengths, including 12 mcg/hour, 25 mcg/hour, 37.5 mcg/hour, 50 mcg/hour, 62.5 mcg/hour, 75 mcg/hour, and 100 mcg/hour

Important Safety Information

Warning

Risk of addiction, abuse, and misuse, as well as respiratory depression, especially when used in combination with other CNS depressants

Contraindications

  • Patients who are not opioid-tolerant
  • Acute or intermittent pain
  • Postoperative pain
  • Mild pain
  • Significant respiratory depression
  • Acute or severe bronchial asthma
  • Known or suspected gastrointestinal obstruction

Adverse Reactions

  • Nausea
  • Vomiting
  • Somnolence
  • Dizziness
  • Insomnia
  • Constipation
  • Hyperhidrosis
  • Fatigue
  • Feeling cold
  • Anorexia
  • Headache
  • Diarrhea

Dosing Recommendations

General Guidance

Dose adjustments should be made based on the patient's response to the medication and their prior opioid usage

Severe and persistent pain

Adult Dose

Initial dose: 25 mcg/hour; titrate every 3 days as needed

Pediatric Dose

Not recommended for pediatric patients under 2 years of age

Special Population Considerations

Pregnancy

  • Use during pregnancy only if the potential benefit justifies the potential risk to the fetus
  • Neonatal opioid withdrawal syndrome may occur

Nursing Mothers

  • Fentanyl is excreted in breast milk; use with caution

Pediatric Use

  • Not recommended for pediatric patients under 2 years of age
  • Use with caution in pediatric patients 2-18 years of age

Geriatric Use

  • Use with caution in geriatric patients
  • Dose adjustments may be necessary due to decreased hepatic and renal function

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