Alfentanil Hydrochloride

ALFENTANIL HYDROCHLORIDE

Manufacturer: Akorn

Score: 144.0

Quick Summary

Alfentanil Hydrochloride is an opioid agonist used as an analgesic adjunct in anesthesia and for monitored anesthesia care. It is administered intravenously and has a rapid onset of action. The drug has several important safety considerations, including the risk of addiction, abuse, and misuse, as well as respiratory depression, muscle rigidity, and interactions with other CNS depressants. Dosage recommendations vary based on the specific use, patient population, and other factors, and special considerations are needed for use in pregnant women, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

Analgesic adjunct in anesthesia
Monitored anesthesia care
Induction of anesthesia for general surgical procedures
Maintenance of anesthesia

Important Safety Information

Warning

Addiction, abuse, and misuse can lead to overdose and death. Assess each patient's risk prior to prescribing Alfentanil HCl Injection.

Contraindications

Hypersensitivity to alfentanil

Adverse Reactions

Respiratory depression
Muscle rigidity
Bradycardia
Hypotension
Nausea
Vomiting

Dosing Recommendations

General Guidance

Reduce the dose in elderly, debilitated, and obese patients, and when administering with CNS depressants.

Analgesic adjunct in anesthesia

Adult Dose

8-20 mcg/kg

Pediatric Dose

Not recommended for patients under 12 years of age

Monitored anesthesia care

Adult Dose

3-8 mcg/kg

Pediatric Dose

Not recommended for patients under 12 years of age

Special Population Considerations

Pregnancy

Prolonged use during pregnancy may cause neonatal opioid withdrawal syndrome
Use only if potential benefits justify potential risks to the fetus

Nursing Mothers

Alfentanil is excreted in human milk, but the effect on the nursing infant is not known

Pediatric Use

Not recommended for patients under 12 years of age due to lack of data

Geriatric Use

Reduce the initial dose by up to 40% due to reduced clearance and increased sensitivity
Monitor for respiratory depression and other adverse reactions

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