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Perindopril Erbumine

PERINDOPRIL ERBUMINE

Manufacturer: Aurobindo Pharma Limited

Score: 148.0

Quick Summary

Perindopril Erbumine is an ACE inhibitor used to treat essential hypertension and stable coronary artery disease. The initial dose for hypertension is 4 mg once daily, which can be titrated up to 16 mg daily, while for stable coronary artery disease, the initial dose is 4 mg once daily for 2 weeks, then increased to 8 mg once daily. Important safety information includes a boxed warning about fetal toxicity, and contraindications such as hypersensitivity to ACE inhibitors, hereditary or idiopathic angioedema, and combination with aliskiren in diabetic patients. Adverse reactions include cough, dizziness, and back pain. Special population considerations include pregnancy, nursing mothers, pediatric use, and geriatric use, with careful monitoring and dose adjustments as needed.

Key Clinical Findings and Indications

  • Essential hypertension
  • Stable coronary artery disease
  • Reduction of cardiovascular mortality or nonfatal myocardial infarction

Important Safety Information

Warning

Fetal toxicity: discontinue use when pregnancy is detected

Contraindications

  • Hypersensitivity to ACE inhibitors
  • Hereditary or idiopathic angioedema
  • Combination with aliskiren in diabetic patients
  • Combination with neprilysin inhibitor

Adverse Reactions

  • Cough
  • Dizziness
  • Back pain
  • Hypotension
  • Hyperkalemia

Dosing Recommendations

General Guidance

Renal impairment: reduce dose or avoid use; elderly: start with low dose and titrate slowly

Essential hypertension

Adult Dose

4 mg once daily, titrated up to 16 mg daily

Pediatric Dose

Not established

Stable coronary artery disease

Adult Dose

4 mg once daily for 2 weeks, then 8 mg once daily

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

  • Category D: discontinue use when pregnancy is detected
  • Fetal toxicity: oligohydramnios, skeletal deformations, and neonatal death

Nursing Mothers

  • Caution: radioactivity detected in milk of lactating rats
  • Monitor for adverse effects in infants

Pediatric Use

  • Not established
  • Neonates with in utero exposure: monitor for hypotension, oliguria, and hyperkalemia

Geriatric Use

  • Start with low dose and titrate slowly
  • Monitor for dizziness and falls
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