Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate, and Amphetamine Sulfate

DEXTROAMPHETAMINE SACCHARATE, AMPHETAMINE ASPARTATE MONOHYDRATE, DEXTROAMPHETAMINE SULFATE, AND AMPHETAMINE SULFATE

Manufacturer: Rhodes Pharmaceuticals L.P.

Score: 144.0

Quick Summary

Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, and Amphetamine Sulfate is a medication used to treat Attention Deficit Hyperactivity Disorder (ADHD) and Narcolepsy. The drug works by stimulating the central nervous system, increasing the levels of certain neurotransmitters in the brain. It is available in various strengths and should be taken at the lowest effective dose. The medication has several potential side effects, including cardiovascular problems, psychiatric adverse events, and growth suppression in children. It is essential to monitor patients for these adverse effects and adjust the dose accordingly. Special considerations should be taken when prescribing this medication to pregnant women, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

Treatment of Attention Deficit Hyperactivity Disorder (ADHD)
Treatment of Narcolepsy
Stimulates the central nervous system
Increases levels of certain neurotransmitters in the brain

Important Safety Information

Warning

Amphetamines have a high potential for abuse and may lead to drug dependence. Misuse may cause sudden death and serious cardiovascular adverse events.

Contraindications

Advanced arteriosclerosis
Symptomatic cardiovascular disease
Moderate to severe hypertension
Hyperthyroidism
Known hypersensitivity or idiosyncrasy to the sympathomimetic amines
Glaucoma
Agitated states
Patients with a history of drug abuse

Adverse Reactions

Cardiovascular palpitations
Tachycardia
Elevation of blood pressure
Sudden death
Myocardial infarction
Psychotic episodes
Overstimulation
Restlessness
Irritability
Euphoria
Dyskinesia
Dysphoria
Depression
Tremor
Tics
Aggression
Anger
Logorrhea
Dermatillomania

Dosing Recommendations

General Guidance

Dose adjustments may be necessary based on individual patient response and tolerability.

ADHD

Adult Dose

5 mg once or twice daily, may be raised in increments of 5 mg at weekly intervals

Pediatric Dose

2.5 mg daily for children 3-5 years, 5 mg once or twice daily for children 6 years and older

Narcolepsy

Adult Dose

5 mg to 60 mg per day in divided doses

Pediatric Dose

5 mg daily for patients 6-12 years, 10 mg daily for patients 12 years and older

Special Population Considerations

Pregnancy

Amphetamines should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus
Infants born to mothers dependent on amphetamines have an increased risk of premature delivery and low birth weight

Nursing Mothers

Amphetamines are excreted in human milk
Mothers taking amphetamines should be advised to refrain from nursing

Pediatric Use

Amphetamines are not recommended for use in children under 3 years of age with ADHD
Long-term effects of amphetamines in children have not been well established

Geriatric Use

Dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate, and amphetamine sulfate tablets have not been studied in the geriatric population

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