Marlido 25 Kit

LIDOCAINE HYDROCHLORIDE, BUPIVACAINE HYDROCHLORIDE, POVIDINE IODINE

Manufacturer: Asclemed USA, Inc.

Score: 146.0

Quick Summary

Marlido 25 Kit is used for local or regional anesthesia, containing lidocaine hydrochloride, bupivacaine hydrochloride, and povidine iodine. It has various clinical applications, including infiltration, nerve block, and epidural anesthesia. However, it comes with important safety information, such as warnings against use in certain conditions like obstetrical paracervical block anesthesia and the potential for systemic toxicity. The drug has specific dosing recommendations, including initial dosing and titration details for adults and considerations for pediatric and geriatric use. Special population considerations include use during pregnancy, nursing mothers, pediatric use, and geriatric use, with specific guidance provided for each scenario.

Key Clinical Findings and Indications

Local or regional anesthesia
Infiltration
Nerve block
Epidural anesthesia
Dental and oral surgery procedures
Diagnostic and therapeutic procedures
Obstetrical procedures

Important Safety Information

Warning

Risk of cardiac arrest with use in obstetrical anesthesia and potential for systemic toxicity

Contraindications

Obstetrical paracervical block anesthesia
Hypersensitivity to bupivacaine or lidocaine
Intravenous regional anesthesia

Adverse Reactions

Cardiovascular effects
Central nervous system effects
Allergic reactions
Methemoglobinemia

Dosing Recommendations

General Guidance

Dose adjustments may be necessary for patients with hepatic or renal impairment

Local infiltration

Adult Dose

Up to 70 mL (without epinephrine) or up to 90 mL (with epinephrine) of 0.25% solution

Pediatric Dose

Reduced dosages commensurate with age, body weight, and physical condition

Epidural anesthesia

Adult Dose

10-20 mL of 0.75% solution (not recommended for obstetrical anesthesia)

Pediatric Dose

Not recommended for pediatric patients younger than 12 years

Special Population Considerations

Pregnancy

Contraindicated for obstetrical paracervical block anesthesia
Use with caution in pregnant women, as it may cause fetal bradycardia and death

Nursing Mothers

Caution should be exercised when administering to nursing women, as it is not known whether the drug is excreted in human milk

Pediatric Use

Not recommended for pediatric patients younger than 12 years
Reduced dosages commensurate with age, body weight, and physical condition may be necessary

Geriatric Use

Patients 65 years and over may be at increased risk for developing hypotension
Dose adjustments may be necessary for geriatric patients, especially those with hypertension or decreased renal function