CELECOXIB
Manufacturer: Viatris Specialty LLC
Score: 144.0
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat various conditions, including osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute pain, and primary dysmenorrhea. It works by inhibiting prostaglandin synthesis, primarily via inhibition of COX-2. The drug has several important safety considerations, including the risk of serious cardiovascular and gastrointestinal events, and is contraindicated in patients with certain conditions, such as known hypersensitivity to celecoxib or sulfonamides. The recommended dosage varies depending on the condition being treated, and special population considerations include use during pregnancy, nursing, pediatric use, and geriatric use.
Risk of serious cardiovascular and gastrointestinal events
Reduce daily dose by 50% in patients with moderate hepatic impairment, and consider dose reduction in patients who are poor metabolizers of CYP2C9 substrates
200 mg once daily or 100 mg twice daily
Not applicable
100 mg to 200 mg twice daily
Not applicable
Not applicable
50 mg twice daily in patients 10 kg to 25 kg, 100 mg twice daily in patients more than 25 kg
200 mg once daily or 100 mg twice daily
Not applicable
400 mg initially, followed by 200 mg dose if needed on first day, then 200 mg twice daily as needed
Not applicable