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Methadone Hydrochloride

METHADONE

Manufacturer: VistaPharm, LLC

Score: 144.0

Quick Summary

Methadone Hydrochloride is used for the management of severe and persistent pain that requires an extended treatment with a daily opioid analgesic and for detoxification or maintenance treatment of opioid addiction. It is a synthetic opioid with multiple actions, including analgesia and opioid detoxification. The medication has a narrow therapeutic index and requires careful dosing and monitoring due to the risk of respiratory depression, overdose, and death. Methadone Hydrochloride should only be prescribed by healthcare professionals knowledgeable about its use and risks, and patients should be closely monitored for signs of addiction, abuse, and misuse.

Key Clinical Findings and Indications

  • Management of severe and persistent pain
  • Detoxification treatment of opioid addiction
  • Maintenance treatment of opioid addiction

Important Safety Information

Warning

Addiction, Abuse, and Misuse; Life-Threatening Respiratory Depression; Accidental Ingestion; Risks From Concomitant Use With Benzodiazepines Or Other CNS Depressants; Neonatal Opioid Withdrawal Syndrome; QT Prolongation

Contraindications

  • Significant respiratory depression
  • Acute or severe bronchial asthma
  • Known or suspected gastrointestinal obstruction
  • Hypersensitivity to methadone

Adverse Reactions

  • Respiratory depression
  • Systemic hypotension
  • Nausea
  • Vomiting
  • Sweating
  • Constipation
  • Euphoria
  • Dysphoria

Dosing Recommendations

General Guidance

Titrate slowly with dose increases no more frequent than every 3 to 5 days

Pain management

Adult Dose

2.5 mg every 8 to 12 hours

Pediatric Dose

Not established

Opioid detoxification

Adult Dose

20 to 30 mg single dose

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

  • Methadone Hydrochloride may be used in pregnancy, but with caution and close monitoring

Nursing Mothers

  • Methadone Hydrochloride is secreted in breast milk, and caution should be exercised when administering to nursing mothers

Pediatric Use

  • The safety and effectiveness of Methadone Hydrochloride have not been established in pediatric patients

Geriatric Use

  • Elderly patients may have increased sensitivity to Methadone Hydrochloride, and dose selection should be cautious

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