Butorphanol Tartrate

Warning

Addiction, abuse, and misuse; life-threatening respiratory depression; neonatal opioid withdrawal syndrome

Contraindications

• Significant respiratory depression
• Acute or severe bronchial asthma
• Known or suspected gastrointestinal obstruction
• Hypersensitivity to butorphanol tartrate or any component of the formulation

Adverse Reactions

• Somnolence
• Dizziness
• Nausea and/or vomiting
• Nasal congestion
• Insomnia

General Guidance

Titrate dose based on individual patient response, with caution advised in elderly patients and those with hepatic or renal impairment

Pregnancy

• Use during pregnancy only if potential benefit justifies potential risk to infant
• Neonatal opioid withdrawal syndrome possible

Nursing Mothers

• Butorphanol detected in milk
• Monitor infant for excess sedation and respiratory depression

Pediatric Use

• Not recommended for use in patients below 18 years of age
• Safety and efficacy not established

Geriatric Use

• Increased sensitivity to butorphanol
• Caution advised due to potential for adverse reactions
• Initial dose of 1 mg, with 90 to 120 minutes between doses