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SEREVENT DISKUS

SALMETEROL XINAFOATE

Manufacturer: GlaxoSmithKline LLC

Score: 144.0

Quick Summary

SEREVENT DISKUS is a long-acting beta2-adrenergic agonist (LABA) used for the treatment of asthma and chronic obstructive pulmonary disease (COPD). It is also used to prevent exercise-induced bronchospasm (EIB). The drug should be used in conjunction with an inhaled corticosteroid (ICS) for asthma treatment, and as a single agent for EIB and COPD. Important safety information includes the risk of asthma-related death, and contraindications include use without an ICS for asthma, primary treatment of status asthmaticus, and severe hypersensitivity to milk proteins or salmeterol. Adverse reactions may include headache, influenza, and throat irritation. Dosing recommendations include 1 inhalation twice daily for asthma and COPD, and 1 inhalation at least 30 minutes before exercise for EIB. Special population considerations include use during pregnancy, pediatric use, and geriatric use, with careful monitoring and dose adjustments as needed.

Key Clinical Findings and Indications

  • Treatment of asthma in patients aged 4 years and older
  • Prevention of exercise-induced bronchospasm (EIB) in patients aged 4 years and older
  • Maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD)

Important Safety Information

Warning

Long-acting beta2-adrenergic agonists (LABA), such as salmeterol, increase the risk of asthma-related death

Contraindications

  • Use without an ICS for asthma
  • Primary treatment of status asthmaticus
  • Severe hypersensitivity to milk proteins or salmeterol

Adverse Reactions

  • Headache
  • Influenza
  • Throat irritation

Dosing Recommendations

General Guidance

No dose adjustments are recommended based on age, gender, or renal function

Asthma

Adult Dose

1 inhalation twice daily

Pediatric Dose

1 inhalation twice daily for patients aged 4 years and older

EIB

Adult Dose

1 inhalation at least 30 minutes before exercise

Pediatric Dose

1 inhalation at least 30 minutes before exercise for patients aged 4 years and older

COPD

Adult Dose

1 inhalation twice daily

Pediatric Dose

Not applicable

Special Population Considerations

Pregnancy

  • Use during pregnancy only if the potential benefit justifies the potential risk to the fetus

Nursing Mothers

  • Use with caution in nursing mothers, as salmeterol is excreted in human milk

Pediatric Use

  • Use with caution in pediatric patients, as the safety and efficacy of salmeterol have not been established in patients younger than 4 years

Geriatric Use

  • Use with caution in geriatric patients, as they may be more sensitive to the effects of salmeterol

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