LAMOTRIGINE
Manufacturer: AvKARE
Score: 144.0
Lamotrigine is an antiepileptic drug used in the treatment of epilepsy and bipolar disorder. It is used as adjunctive therapy for partial-onset seizures, primary generalized tonic-clonic seizures, and generalized seizures of Lennox-Gastaut syndrome in patients aged 2 years and older. Lamotrigine is also used for the maintenance treatment of bipolar I disorder to delay the time to occurrence of mood episodes. The drug has a boxed warning for serious skin rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis, which can be life-threatening. Important safety information includes the risk of suicidal thoughts and behaviors, and contraindications include hypersensitivity to the drug or its ingredients.
Serious skin rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis, can occur
Dose adjustments may be necessary based on concomitant medications, renal or hepatic impairment, and pregnancy status
25 mg every other day, increasing to 100-400 mg/day
0.15 mg/kg/day, increasing to 1-5 mg/kg/day
25 mg every other day, increasing to 100-400 mg/day
Not established