VALSARTAN
Manufacturer: Camber Pharmaceuticals, Inc.
Score: 144.0
Valsartan is an angiotensin II receptor blocker (ARB) used to treat hypertension, heart failure, and to reduce cardiovascular mortality in patients with left ventricular failure or left ventricular dysfunction following myocardial infarction. It works by blocking the action of angiotensin II, a potent vasoconstrictor, which leads to a decrease in blood pressure and a reduction in the risk of cardiovascular events. The recommended starting dose of valsartan is 80 mg or 160 mg once daily, with a maximum dose of 320 mg daily. Valsartan is generally well-tolerated, but can cause adverse reactions such as headache, dizziness, and hyperkalemia. It is contraindicated in patients with known hypersensitivity to any component of the drug and should be used with caution in patients with renal or hepatic impairment, as well as in pregnant or nursing women.
When pregnancy is detected, discontinue valsartan as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
No initial dosage adjustment is required for elderly patients, for patients with mild or moderate renal impairment, or for patients with mild or moderate liver insufficiency. Care should be exercised with dosing of valsartan in patients with hepatic or severe renal impairment.
80 mg or 160 mg once daily, with a maximum dose of 320 mg daily
1.3 mg/kg once daily (up to 40 mg total) for children 6-16 years old
40 mg twice daily, with a maximum dose of 160 mg twice daily
Not recommended for pediatric patients under 6 years old
20 mg twice daily, with a maximum dose of 160 mg twice daily
Not recommended for pediatric patients under 6 years old