ASENAPINE
Manufacturer: Alembic Pharmaceuticals Inc.
Score: 144.0
Asenapine is an atypical antipsychotic used for the treatment of bipolar I disorder, including acute monotherapy of manic or mixed episodes in pediatric patients 10 to 17 years of age, and as adjunctive therapy to lithium or valproate in adults. The mechanism of action is unknown, but it exhibits high affinity for serotonin and dopamine receptors. Important safety information includes a boxed warning for increased mortality in elderly patients with dementia-related psychosis, and contraindications include severe hepatic impairment and hypersensitivity reactions. Common adverse reactions include somnolence, oral hypoesthesia, and fatigue. The recommended dosing is 2.5 mg to 10 mg twice daily for pediatric patients and 5 mg to 10 mg twice daily for adults, with dose adjustments based on individual response and tolerability. Special population considerations include use during pregnancy, pediatric use, and geriatric use, with careful monitoring recommended due to increased risk of adverse reactions.
Increased mortality in elderly patients with dementia-related psychosis
Dose adjustments based on individual response and tolerability
5 mg to 10 mg twice daily
2.5 mg to 10 mg twice daily
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