Home About
Back to Search

Symbyax

OLANZAPINE AND FLUOXETINE HYDROCHLORIDE

Manufacturer: Eli Lilly and Company

Score: 144.0

Quick Summary

Symbyax is a combination of olanzapine and fluoxetine used for the treatment of depressive episodes associated with bipolar I disorder and treatment-resistant depression. It should be used with caution due to the risk of suicidal thoughts and behaviors, particularly in children, adolescents, and young adults. The recommended starting dose is 6 mg/25 mg once daily, with a maximum dose of 12 mg/50 mg. Special considerations are needed for patients with certain medical conditions, pregnant or nursing women, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

  • Treatment of depressive episodes associated with bipolar I disorder
  • Treatment of treatment-resistant depression
  • Combination of olanzapine and fluoxetine

Important Safety Information

Warning

Increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults

Contraindications

  • Monoamine oxidase inhibitors (MAOIs)
  • Pimozide
  • Thioridazine

Adverse Reactions

  • Suicidal thoughts and behaviors
  • Serotonin syndrome
  • Neuroleptic malignant syndrome
  • Hyperglycemia
  • Dyslipidemia
  • Weight gain

Dosing Recommendations

General Guidance

Dose adjustments may be necessary for patients with certain medical conditions, such as hepatic impairment or those taking other medications

Depressive episodes associated with bipolar I disorder

Adult Dose

6 mg/25 mg once daily

Pediatric Dose

3 mg/25 mg once daily (for ages 10-17 years)

Treatment-resistant depression

Adult Dose

6 mg/25 mg once daily

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

  • Use with caution due to potential risks to the fetus
  • Pregnancy exposure registry available

Nursing Mothers

  • Use with caution due to potential risks to the infant
  • Monitor infant for adverse reactions

Pediatric Use

  • Approved for use in patients 10-17 years of age with bipolar I disorder
  • Not established for use in patients less than 10 years of age

Geriatric Use

  • Use with caution due to potential risks of increased sedation, orthostatic hypotension, and other adverse reactions
  • Dose adjustments may be necessary

Similar Drugs

Olanzapine

OLANZAPINE

Macleods Pharmaceuticals Limited

Similarity: 66.4%

OLANZAPINE

OLANZAPINE

Eugia US LLC

Similarity: 66.4%

OLANZAPINE

OLANZAPINE

AvPAK

Similarity: 66.4%

Olanzapine

OLANZAPINE

Major Pharmaceuticals

Similarity: 66.4%

Olanzapine

OLANZAPINE

Bryant Ranch Prepack

Similarity: 66.4%

Zyprexa

OLANZAPINE

Eli Lilly and Company

Similarity: 66.4%

Olanzapine

OLANZAPINE

Aurobindo Pharma Limited

Similarity: 66.4%

Olanzapine

OLANZAPINE

RedPharm Drug

Similarity: 66.4%

Olanzapine

OLANZAPINE

Sandoz Inc

Similarity: 66.4%

Olanzapine

OLANZAPINE

Aphena Pharma Solutions - Tennessee, LLC

Similarity: 66.4%

Olanzapine

OLANZAPINE

Golden State Medical Supply, Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

olanzapine

OLANZAPINE

Zydus Pharmaceuticals USA Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Dr. Reddy's Laboratories Ltd.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Bryant Ranch Prepack

Similarity: 66.4%

Olanzapine

OLANZAPINE

Dr. Reddy's Laboratories Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

RedPharm Drug

Similarity: 66.4%

Olanzapine

OLANZAPINE

Macleods Pharmaceuticals Limited

Similarity: 66.4%

Olanzapine

OLANZAPINE

Bryant Ranch Prepack

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

NorthStar RxLLC

Similarity: 66.4%

Olanzapine

OLANZAPINE

Proficient Rx LP

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Camber Pharmaceuticals, Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Bryant Ranch Prepack

Similarity: 66.4%

Olanzapine

OLANZAPINE

Aurobindo Pharma Limited

Similarity: 66.4%

Olanzapine

OLANZAPINE

Proficient Rx LP

Similarity: 66.4%

Olanzapine

OLANZAPINE

Sandoz Inc

Similarity: 66.4%

Olanzapine

OLANZAPINE

Apotex Corp.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Bryant Ranch Prepack

Similarity: 66.4%

Olanzapine

OLANZAPINE

Bryant Ranch Prepack

Similarity: 66.4%

Olanzapine

OLANZAPINE

PD-Rx Pharmaceuticals, Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Coupler LLC

Similarity: 66.4%

Olanzapine

OLANZAPINE

Major Pharmaceuticals

Similarity: 66.4%

Olanzapine

OLANZAPINE

Cardinal Health 107, LLC

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Bryant Ranch Prepack

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Apotex Corp.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Cadila Pharmaceuticals Limited

Similarity: 66.4%

Olanzapine

OLANZAPINE

Preferred Pharmaceuticals Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Proficient Rx LP

Similarity: 66.4%

Olanzapine

OLANZAPINE

Aurobindo Pharma Limited

Similarity: 66.4%

Olanzapine

OLANZAPINE

Bryant Ranch Prepack

Similarity: 66.4%

OLANZAPINE

OLANZAPINE

Torrent Pharmaceuticals Limited

Similarity: 66.4%

Olanzapine

OLANZAPINE

Ascend Laboratories, LLC

Similarity: 66.4%

Olanzapine

OLANZAPINE

NCS HealthCare of KY, LLC dba Vangard Labs

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Proficient Rx LP

Similarity: 66.4%

Olanzapine

OLANZAPINE

Golden State Medical Supply, Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Proficient Rx LP

Similarity: 66.4%

Zyprexa

OLANZAPINE

H2-Pharma LLC

Similarity: 66.4%

Olanzapine

OLANZAPINE

Preferred Pharmaceuticals Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Modavar Pharmaceuticals LLC

Similarity: 66.4%

Olanzapine

OLANZAPINE

Qilu Pharmaceutical Co., Ltd.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Indoco Remedies Limited

Similarity: 66.4%

Olanzapine

OLANZAPINE

NuCare Pharmceuticals,Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Strides Pharma Science Limited

Similarity: 66.4%

Olanzapine

OLANZAPINE

Mylan Pharmaceuticals Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Bryant Ranch Prepack

Similarity: 66.4%

Olanzapine

OLANZAPINE

Cardinal Health 107, LLC

Similarity: 66.4%

Olanzapine

OLANZAPINE

NCS HealthCare of KY, Inc dba Vangard Labs

Similarity: 66.4%

Olanzapine

OLANZAPINE

RPK Pharmaceuticals, Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

OLANZAPINE

OLANZAPINE

Burel Pharmaceuticals, LLC

Similarity: 66.4%

OLANZAPINE

OLANZAPINE

Eugia US LLC

Similarity: 66.4%

Olanzapine

OLANZAPINE

Upsher-Smith Laboratories, LLC

Similarity: 66.4%

Olanzapine

OLANZAPINE

American Regent, Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Teva Pharmaceuticals USA, Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Preferred Pharmaceuticals Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Major Pharmaceuticals

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

REMEDYREPACK INC.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Bryant Ranch Prepack

Similarity: 66.4%

Olanzapine

OLANZAPINE

A-S Medication Solutions

Similarity: 66.4%

Olanzapine

OLANZAPINE

Bryant Ranch Prepack

Similarity: 66.4%

Olanzapine

OLANZAPINE

American Health Packaging

Similarity: 66.4%

Olanzapine

OLANZAPINE

Proficient Rx LP

Similarity: 66.4%

Olanzapine

OLANZAPINE

Par Pharmaceutical, Inc.

Similarity: 66.4%

Olanzapine

OLANZAPINE

American Health Packaging

Similarity: 66.4%

Olanzapine

OLANZAPINE

Dr. Reddy's Laboratories Ltd.

Similarity: 66.4%

Olanzapine

OLANZAPINE

Dr.Reddy's Laboratories Limited

Similarity: 66.4%

Olanzapine

OLANZAPINE

Bryant Ranch Prepack

Similarity: 66.4%

Olanzapine

OLANZAPINE

RPK Pharmaceuticals, Inc.

Similarity: 66.4%

Fluoxetine

FLUOXETINE

Cardinal Health 107, LLC

Similarity: 64.3%
Back to Search