Home About
Back to Search

Naproxen and esomeprazole magnesium

NAPROXEN AND ESOMEPRAZOLE MAGNESIUM

Manufacturer: Dr. Reddy's Laboratories Limited

Score: 144.0

Quick Summary

Naproxen and esomeprazole magnesium delayed-release tablets are a combination of naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and esomeprazole magnesium, a proton pump inhibitor (PPI), used for the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis in adults, and juvenile idiopathic arthritis (JIA) in adolescent patients. The esomeprazole component is used to decrease the risk of developing naproxen-associated gastric ulcers.

Key Clinical Findings and Indications

  • Relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis in adults
  • Relief of signs and symptoms of juvenile idiopathic arthritis (JIA) in adolescent patients
  • Decrease the risk of developing naproxen-associated gastric ulcers

Important Safety Information

Warning

Cardiovascular thrombotic events, GI bleeding, ulceration, and perforation

Contraindications

  • Known hypersensitivity to naproxen, esomeprazole magnesium, or any components of the drug product
  • History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
  • In the setting of coronary artery bypass graft (CABG) surgery
  • Patients receiving rilpivirine-containing products

Adverse Reactions

  • Gastritis
  • Diarrhea
  • Upper respiratory tract infection
  • Flatulence
  • Headache
  • Urinary tract infection
  • Dysgeusia

Dosing Recommendations

General Guidance

Avoid in moderate/severe renal impairment or severe hepatic impairment. Consider dose reduction in mild/moderate hepatic impairment.

Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis

Adult Dose

One naproxen and esomeprazole magnesium delayed-release tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole or 500 mg of naproxen/20 mg of esomeprazole

Pediatric Dose

Not applicable

Juvenile Idiopathic Arthritis (JIA) in Adolescent Patients

Adult Dose

Not applicable

Pediatric Dose

One naproxen and esomeprazole magnesium delayed-release tablet twice daily of 375 mg naproxen/20 mg of esomeprazole for patients weighing 38 kg to less than 50 kg

Special Population Considerations

Pregnancy

  • Use of NSAIDs, including naproxen and esomeprazole magnesium delayed-release tablets, can cause premature closure of the fetal ductus arteriosus and fetal and renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment

Nursing Mothers

  • Naproxen is excreted in human milk, and it is not known whether esomeprazole is excreted in human milk

Pediatric Use

  • The safety and effectiveness of naproxen and esomeprazole magnesium delayed-release tablets have been established in adolescent patients 12 years of age and older weighing at least 38 kg for the symptomatic relief of JIA and to decrease the risk of developing naproxen-associated gastric ulcers

Geriatric Use

  • Elderly patients, compared to younger patients, are at greater risk for NSAID-associated serious cardiovascular, gastrointestinal, and/or renal adverse reactions

Similar Drugs

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Advanced Rx of Tennessee, LLC

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Preferred Pharmaceuticals, Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

NuCare Pharmaceuticals,Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

NuCare Pharmaceuticals,Inc.

Similarity: 71.7%

Esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Ascend Laboratories, LLC

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Preferred Pharmaceuticals Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

PD-Rx Pharmaceuticals, Inc.

Similarity: 71.7%

esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Bryant Ranch Prepack

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

NCS HealthCare of KY, LLC dba Vangard Labs

Similarity: 71.7%

esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

NuCare Pharmaceuticals,Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Preferred Pharmaceuticals Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

A-S Medication Solutions

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

NuCare Pharmaceuticals,Inc.

Similarity: 71.7%

esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Biocon Pharma Inc.,

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Preferred Pharmaceuticals, Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

NuCare Pharmaceuticals,Inc.

Similarity: 71.7%

esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

REMEDYREPACK INC.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

A-S Medication Solutions

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

NuCare Pharmaceuticals,Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

NuCare Pharmaceuticals,Inc.

Similarity: 71.7%

esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Proficient Rx LP

Similarity: 71.7%

esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Preferred Pharmaceuticals Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Advanced Rx of Tennessee, LLC

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Quality Care Products, LLC

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Lannett Company, Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

medsourcer pharmaceuticals

Similarity: 71.7%

esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Zydus Pharmaceuticals USA Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Bryant Ranch Prepack

Similarity: 71.7%

esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Preferred Pharmaceuticals Inc.

Similarity: 71.7%

Esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Aphena Pharma Solutions - Tennessee, LLC

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Proficient Rx LP

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Mylan Pharmaceuticals Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

PD-Rx Pharmaceuticals, Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Teva Pharmaceuticals USA, Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

A-S Medication Solutions

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

A-S Medication Solutions

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Bryant Ranch Prepack

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Aurobindo Pharma Limited

Similarity: 71.7%

Esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Bryant Ranch Prepack

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Zydus Pharmaceuticals USA Inc.

Similarity: 71.7%

Esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Sun Pharmaceutical Industries, Inc

Similarity: 71.7%

Esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Rising Pharma Holdings, Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Quality Care Products, LLC

Similarity: 71.7%

ESOMEPRAZOLE MAGNESIUM

ESOMEPRAZOLE MAGNESIUM

Cipla USA Inc.

Similarity: 71.7%

esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Graviti Pharmaceuticals Private Limited

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Proficient Rx LP

Similarity: 71.7%

esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Bryant Ranch Prepack

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

NorthStar Rx LLC

Similarity: 71.7%

Esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

NuCare Pharmaceuticals,Inc.

Similarity: 71.7%

Esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

NuCare Pharmaceuticals,Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Glenmark Pharmaceuticals Inc., USA

Similarity: 71.7%

Esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Granules Pharmaceuticals Inc.

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

NuCare Pharmaceuticals,Inc.

Similarity: 71.7%

Esomeprazole magnesium

ESOMEPRAZOLE MAGNESIUM

Bryant Ranch Prepack

Similarity: 71.7%

Esomeprazole Magnesium

ESOMEPRAZOLE MAGNESIUM

Aurobindo Pharma Limited

Similarity: 71.7%

Naproxen Sodium

NAPROXEN SODIUM

Amneal Pharmaceuticals of New York LLC

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Aurobindo Pharma Limited

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Alvogen Inc.

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

ScieGen Pharmaceuticals, Inc.

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Upsher-Smith Laboratories, LLC

Similarity: 69.9%

Anaprox DS

NAPROXEN SODIUM

Canton Laboratories

Similarity: 69.9%

Naproxen

NAPROXEN SODIUM

Northwind Pharmaceuticals, LLC

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Bryant Ranch Prepack

Similarity: 69.9%

Naproxen

NAPROXEN SODIUM

REMEDYREPACK INC.

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Proficient Rx LP

Similarity: 69.9%

Naprelan

NAPROXEN SODIUM

ALMATICA PHARMA INC.

Similarity: 69.9%

Naproxen

NAPROXEN SODIUM

Granules India Ltd

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Proficient Rx LP

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Bryant Ranch Prepack

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

AvPAK

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Bryant Ranch Prepack

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

SA3, LLC

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Bryant Ranch Prepack

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

RPK Pharmaceuticals, Inc.

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Preferred Pharmaceuticals, Inc.

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Teva Pharmaceuticals, Inc.

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

ST. MARY'S MEDICAL PARK PHARMACY

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Bryant Ranch Prepack

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

REMEDYREPACK INC.

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Glenmark Pharmaceuticals Inc., USA

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Medsource Pharmaceuticals

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Asclemed USA, Inc.

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

Bryant Ranch Prepack

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

PD-Rx Pharmaceuticals, Inc.

Similarity: 69.9%

Naproxen Sodium

NAPROXEN SODIUM

PD-Rx Pharmaceuticals, Inc.

Similarity: 69.9%

esomeprazole

ESOMEPRAZOLE

Macleods Pharmaceuticals Limited

Similarity: 68.5%

Naproxen Oral Suspension

NAPROXEN ORAL

Novitium Pharma LLC

Similarity: 65.2%

RABEPRAZOLE SODIUM

RABEPRAZOLE SODIUM

Medsource Pharmaceuticals

Similarity: 60.4%
Back to Search