Letrozole

Warning

Letrozole can cause fetal harm when administered to a pregnant woman

Contraindications

• Pregnancy
• Known hypersensitivity to the active substance or any of the excipients

Adverse Reactions

• Hot flashes
• Arthralgia
• Fatigue
• Hypercholesterolemia
• Osteoporosis

General Guidance

No dose adjustment is required for patients with renal impairment if creatinine clearance is greater than or equal to 10 mL/min

Pregnancy

• Letrozole can cause fetal harm when administered to a pregnant woman
• Pregnancy testing is recommended prior to starting treatment with letrozole

Nursing Mothers

• It is not known whether letrozole is excreted in human milk
• Caution should be exercised when letrozole is administered to a nursing woman

Pediatric Use

• The safety and effectiveness of letrozole in pediatric patients have not been established
• Letrozole is not recommended for use in pediatric patients

Geriatric Use

• No overall differences in safety or efficacy were observed between elderly patients and younger patients
• Greater sensitivity of some older individuals cannot be ruled out