Tizanidne hydrochloride

Warning

Contraindicated with potent CYP1A2 inhibitors, warnings for hypotension, liver injury, sedation, hallucinosis, and hypersensitivity reactions

Contraindications

• Potent CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)

Adverse Reactions

• Dry mouth
• Somnolence
• Asthenia
• Dizziness
• Urinary tract infection
• Constipation
• Liver function tests abnormal
• Vomiting
• Speech disorder
• Amblyopia
• Urinary frequency
• Flu syndrome
• Dyskinesia
• Nervousness
• Pharyngitis
• Rhinitis

General Guidance

Dose adjustments necessary for patients with renal or hepatic impairment

Pregnancy

• No adequate data on developmental risk
• Use with caution

Nursing Mothers

• No adequate data on effects on nursing infants
• Use with caution

Pediatric Use

• Safety and effectiveness not established

Geriatric Use

• Use with caution due to increased risk of adverse reactions
• Dose adjustments necessary for patients with renal impairment