Nifedipine

NIFEDIPINE

Manufacturer: Bryant Ranch Prepack

Score: 141.0

Quick Summary

Nifedipine is a calcium channel blocker used to treat hypertension. It works by relaxing blood vessels, which helps to lower blood pressure. The usual maintenance dose is 30-60 mg once daily, and it should be taken on an empty stomach. Nifedipine has several potential side effects, including peripheral edema, headache, and flushing. It is contraindicated in patients with certain medical conditions, such as cardiogenic shock, and it should be used with caution in patients with liver or kidney disease. Nifedipine is also not recommended for use during pregnancy or breastfeeding, and its safety and effectiveness in pediatric patients have not been established.

Key Clinical Findings and Indications

Nifedipine is used to treat hypertension
It works by relaxing blood vessels and lowering blood pressure
The usual maintenance dose is 30-60 mg once daily

Important Safety Information

Warning

Nifedipine can cause excessive hypotension, increased angina and/or myocardial infarction, and congestive heart failure

Contraindications

Concomitant administration with strong P450 inducers, such as rifampin
Cardiogenic shock
Known hypersensitivity to any component of the tablet

Adverse Reactions

Peripheral edema
Headache
Flushing
Dizziness
Fatigue/asthenia
Nausea

Dosing Recommendations

General Guidance

Dose adjustments should be made based on therapeutic efficacy and safety

Hypertension

Adult Dose

30 mg once daily, titrated over 7-14 days

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Nifedipine should be used with caution during pregnancy
There are no adequate and well-controlled studies in pregnant women

Nursing Mothers

Nifedipine is excreted in human milk
Nursing mothers are advised not to breastfeed their babies when taking the drug

Pediatric Use

The safety and effectiveness of nifedipine in pediatric patients have not been established

Geriatric Use

Dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range
Elderly patients may be more susceptible to the effects of nifedipine due to decreased hepatic, renal, or cardiac function

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